Oxidative Cascade Prognosis, Antioxidants &Selected Trace Elements in COVID-19

• 作者: Karimah Mohammed Rabiu Rizwan Ahmad Ansari
• 来源期刊: 应用科学(英文)
• 学科: 数学
• 关键词: COVID-19 COPD ROS Oxidative Stress CYTOKINES Inflammation
• 年，卷（期）: 2020,（11）
• 页码范围: 688-700
• 页数: 13页
• 分类号: O17

摘要

COVID-19 pandemic has now become a challenging global public health concern, having higher risk of developing fatal respiratory disease due to severe inflammatory responses associated with the virus-mediated oxidative stress. The respiratory system is most preferred target organ for this novel virus as the lung is well oxygenated and having large surface area available to the virus for exposure and successively augmenting the health complications. Oxidative stress (OS) is an important factor causing metabolic and physiological alteration and various disease augmentations within the body. Respiratory viral infection has general consociation with cytokine production, inflammation, cell death and other pathophysiological processes which may be the result of perturbed redox balance. Apart from this, the presence of conditions likes aging, diabetes and hypertension and chronic obstructive pulmonary diseases (COPD) are the risk factor for making severity of such infection outcome. It has been well established that an overproduction of reactive oxygen species (ROS) and antioxidant mechanisms deprivation are vital step for viral replica production and consequent release of pro-inflammatory cytokines </span><span style="font-family:Verdana;">is</span><span style="font-family:Verdana;"> also an important factor of the innate immune responses to the pathogens that may result into acute lung damage. Additionally</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> ROS can damage various vital biological molecules and inactivation of essential enzymes. Oxidative stress is an important factor causing metabolic and other pathophysiological alterations</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> such as protein oxidations and various associated diseases. Therefore, in this paper</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> the significant adverse impact of virus on host cell and underlying possible biochemical mechani