Low-intensity pulsed ultrasound for regenerating peripheral nerves: potential for penile nerve

• 作者: Amanda B Reed-Maldonado Dong-Yi Peng Gui-Ting Lin Shu-Jie Xia Tom F Lue
• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2020,（4）
• 页码范围: 335-341
• 页数: 7页
• 语种: 英文
• DOI: 10.4103/aja.aja_95_19

摘要

Peripheral nerve damage,such as that found after surgery or trauma,is a substantial clinical challenge.Much research continues in attempts to improve outcomes after peripheral nerve damage and to promote nerve repair after injury.In recent years,lowintensity pulsed ultrasound (LIPUS) has been studied as a potential method of stimulating peripheral nerve regeneration.In this review,the physiology of peripheral nerve regeneration is reviewed,and the experiments employing LIPUS to improve peripheral nerve regeneration are discussed.Application of LIPUS following nerve surgery may promote nerve regeneration and improve functional outcomes through a variety of proposed mechanisms.These include an increase of neurotrophic factors,Schwann cell (SC) activation,cellular signaling activations,and induction of mitosis.We searched PubMed for articles related to these topics in both in vitro and in vivo animal research models.We found numerous studies,suggesting that LIPUS following nerve surgery promotes nerve regeneration and improves functional outcomes.Based on these findings,LIPUS could be a novel and valuable treatment for nerve injury-induced erectile dysfunction.