BET inhibition, prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2020,（5）
• 页码范围: 397-399
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/jmcb/mjz114

摘要

Dear Editor, Cohesin is a multiprotein complex that not only is essential for cell division but also has key roles in genome organization that underpin its gene regulatory function.Recurrent mutations of genes encoding cohesin subunits occur in myeloid malignancies at 10％-12％ (Kon et al.,2013),and the frequency of cohesin mutation in Down syndromeassociated megakaryoblastic leukaemia is even higher (～50％) (Yoshida et al.,2013).