Anticholinergic medications even in therapeutic range can cause recurrence of psychosis

• 作者: Barikar Chandrappa Malathesh Seshadri Sekhar Chatterjee Soumitra Das
• 来源期刊: 综合精神医学(英文)
• 学科: 医学
• 关键词: CHOLINERGIC drugs PRESCRIBED
• 年，卷（期）: zhjsyxyw_2020,（4）
• 页码范围: 245-246
• 页数: 2页
• 分类号: R74

摘要

Anticholinergic drugs are commonly used in psychiatry to attenuate antipsychotic induced extrapyramidal syndrome(EPS).Psychosis as a side effect is generally explained under the rubric of anticholinergic toxicity or induced delirium.Anticholinergic induced worsening of psychosis in patients with normal cognition is extremely rare in literature.Here,we arepresenting a case of young female who was prescribed with multiple anticholinergics to reduce EPS,and each time had worsening of psychosis with intact cognition.We then discussed the possible neurobiological explanation with special reference to muscarinic hypothesis of schizophrenia.