Cannabidiol(CBD) is a physiologically active natural substance, usually extracted from the flowers and leaves of hemp. CBD not only has the function of alleviating the symptoms of many mental disorders, but also has the function of anti-inflammation, anti-oxidation and treatment of skin diseases. Because of its beneficial effects, CBD has been used as an important raw material in the production of health care products and skin care products, which have already been sold on the market. This paper reviewed the main preparation techniques of CBD. The author developed a new refining process for CBD purification combining molecular distillation and crystallization. This new process is both environmental friendly and economical. The obtained samples meet the requirements of the cosmetic industry. The paper also introduces the application prospect of CBD products in daily Chemical Industry, especially in skin care.