Based on the analysis of the security problems existing in the cloud platform of the data center, this paper proposes a set of cloud platform security protection scheme being with virtualization technology. This paper focuses on the overall architecture of cloud platform as well as the design of virtualization security architecture. Meantime, it introduces the key technologies of VXLAN in detail. The scheme realizes flexible scheduling of security resources through virtual pooling of independent security gateway and virtual machine isolation through VXLAN technology. Moreover, it guides all horizontal traffic to independent security gateway for processing, unified management of security gateway through cloud platform by using Huawei NSH business chain technology. This scheme effectively solves the horizontal transmission of security threat among virtual machines, and realizes the fine security control and protection for the campus data center.