COVID-19 and diabetes:the contributions of hyperglycemia

• 作者: Jing Wang Wen Meng
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Perspectives
• 页码范围: 958-962
• 页数: 5页
• 语种: 英文
• DOI: 10.1093/jmcb/mjaa054

摘要

Coronavirus disease 2019(COVID-19)caused by coronavirus SARS-CoV-2 infec-tion has now evolved into a worldwide cri-sis that triggers substantial morbidity and mortality.COVID-19 occurs more fre-quently and has more serious complica-tions in patients with diabetes mellitus,but the underlying mechanisms remain largely elusive.Here,we summarize cur-rent and evolving concepts on the detri-mental effect of hyperglycemia on SARS-CoV-2 infection and consequences,focus-ing on several key mechanisms underly-ing the link between diabetes and COVID-19.A better understanding of the mecha-nisms by which hyperglycemia worsens the prognosis of COVID-19 is critical for reducing the risk of SARS-CoV-2 infection and its associated mortality.