Advanced biomaterials for cancer immunotherapy

• 作者: Fan Yang Jin-rong Peng Kun Shi Yan-peng Jia Ying Hao Zhi-yong Qian
• 来源期刊: 中国药理学报（英文版）
• 关键词: cancer immunotherapy nanobiomaterials nanoparticles liposomes micelles hydrogel microneedles dendritic cells (DCs)
• 年，卷（期）: 2020,（7）
• 页码范围: 911-927
• 页数: 17页
• 语种: 英文

摘要

Immunotherapy,as a powerful strategy for cancer treatment,has achieved tremendous efficacy in clinical trials.Despite these advancements,there is much to do in terms of enhancing therapeutic benefits and decreasing the side effects of cancer immunotherapy.Advanced nanobiomaterials,including liposomes,polymers,and silica,play a vital role in the codelivery of drugs and immunomodulators.These nanobiomaterial-based delivery systems could effectively promote antitumor immune responses and simultaneously reduce toxic adverse effects.Furthermore,nanobiomaterials may also combine with each other or with traditional drugs via different mechanisms,thus giving rise to more accurate and efficient tumor treatment.Here,an overview of the latest advancement in these nanobiomaterials used for cancer immunotherapy is given,describing outstanding systems,including lipid-based nanoparticles,polymer-based scaffolds or micelles,inorganic nanosystems,and others.