CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value

• 作者: Bin Xu Jie Wu Lan Li Siyi Wu
• 来源期刊: 癌症生物学与医学（英文版）
• 年，卷（期）: 2020,（3）
• 页码范围: 528-542
• 页数: 15页
• 语种: 英文
• DOI: 10.20892/j.issn.2095-3941.2020.0032

摘要

The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emergingin vivo andin vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.