N^6-methyladenosine as a Novel Regulator of Brain Physiology and Diseases

• 作者: Bing HAN Hong-hong YAO
• 来源期刊: 当代医学科学(英文)
• 学科: 医学
• 关键词: m^6A BRAIN PHYSIOLOGY DISEASES
• 年，卷（期）: 2020,（3）
• 页码范围: 401-406
• 页数: 6页
• 分类号: R32

摘要

N^6-methyladenosine(m6A)is identified as the most widespread and abundant internal chemical modification of RNA in eukaryotes.A series of proteins including methyltransferases(also known as“writers”),demethylases(also known as“erasers”),and m6A-binding proteins(also known as“readers”)were indicated to participate in the m6A methylation.m6A has emerged as a regulator of various cellular,developmental,and disease processes.Notably,there is highest abundance of m^6A methylation in brain than in other organs,which indicates that m^6A plays an essential role in brain functions.Here,we describe the general features,mechanisms,and functions of m^6A in the brain,and discuss the emerging roles of m6A in brain physiology and diseases.