Inhibitory effect of cyclocytidine hydrochloride on vesicular stomatitis virus infection

• 作者: Chenxiao Huang Chuyi Hou Jianfeng Dai Jinyu Zhang Kezhen Wang Qi Zhang Wen Pan Yanmei Li Yunfei Ge
• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2020,（5）
• 页码范围: 576-579
• 页数: 4页
• 语种: 英文
• DOI: 10.1093/abbs/gmaa017

摘要

Plants and plant derivatives are natural sources of valuable material for the discovery and development of new antiviral materials due to their high availability in nature and expected low side effects [1].In fact, the extract from plants has displayed good antiviral effects comparing with their synthetic analogues [2].More and more natural products derived from diverse parts of plants have been used as antiviral drugs during the past several decades, such as baicalein, emodin, dandelion, and berberine [3-6].Cyclocytidine hydrochloride (Fig.1A), an anhydride analogue of cytosine arabinoside (araC), has been used in medicine as clinical chemotherapeutics with strong antileukemic activity [7].Previous studies also showed that cyclocytidine hydrochloride exhibits high antiviral activity against DNA virus, such as herpes simplex virus (HSV) andcytomegalovirus (CMV) [8-10].However, whether this natural compound has impact on RNA virus is still unknown.So it gives us great interest to investigate the mechanisms of cyclocytidine hydrochloride under RNA virus infection.