Elaboration of phosphoramidite ligands enabling palladiumcatalyzed diastereo-and enantioselective all carbon [4+3]cycloaddition

• 作者: Hao Sun Wei-Ping Deng Wu-Lin Yang Xing Zheng
• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2020,（7）
• 页码范围: 911-916
• 页数: 6页
• 语种: 英文

摘要

A palladium-catalyzed diastereo-and enantioselective all carbon [4+3] cycloaddition oftrimethylenemethane was developed by employing the elaborate tetrahydroquinoline-derived phosphoramidite ligand.The exclusive regioselectivity was realized by using the aromatization-driven diene indole-2,3-quinodimethanes,affording biologically important cyclohepta[b]indoles with excellent diastereo-,and enantioselectivities (up to ＞20∶1 dr,＞99％ ee).Furthermore,the more challenging pyrrolidone-3,4-dienes,in the absence of aromatization force,were also compatible inthereaction,providing novel cyclohepta[c]pyrrol-1(2H)-ones with excellent regio-,diastereo-,and enantioselectivities (up to ＞20∶1 rr,＞20∶1 dr,＞99％ ee).

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Xing Zheng		1	0	0.0	0.0
2	Hao Sun		1	0	0.0	0.0
3	Wu-Lin Yang		1	0	0.0	0.0
4	Wei-Ping Deng		1	0	0.0	0.0