Copper-thioguanine metallodrug with self-reinforcing circular catalysis for activatable MRI imaging and amplifying specificity of cancer therapy

• 作者: Chan Yang Cheng Zhang1 Guosheng Song Haifeng Yuan Hongmin Meng Shuangyan Huan Xiaobing Zhang Yan Zhao Yue Yang
• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2020,（7）
• 页码范围: 924-935
• 页数: 12页
• 语种: 英文

摘要

For chemotherapy,drug delivery systems often suffer from the inefficient drug loading capability,which usually cause systems toxicity and extra burden to excrete carrier itself.Moreover,the cancer therapeutic efficacy is also greatly limited by the specificity of tumor microenvironment for reactive oxygen species (ROS) based cancer therapeutic strategy (e.g.,chemodynamic therapy).Herein,we have developed metal-drug coordination nanoplatform that can not only be responsive to tumor micro environment but also modulate it,so as to achieve efficient treatment of cancer.Excitingly,by employing small molecule drug (6-thioguanine) as ligand copper ions,we achieve a high drug loading rate (60.1％) and 100％ of utilization of metal-drug coordination nanoplatform (Cu-TG).Interestingly,Cu-TG possessed high-efficiently horseradish peroxidase-like,glutathione peroxidase-like and catalase-like activity.Under the tumor microenvironment,Cu-TG exhibited the self-reinforcing circular catalysis that is able to amplify the cellular oxidative stress,inducing notable cancer cellular apoptosis.Moreover,Cu-TG could be activated with glutathione (GSH) and facilitated for GSH triggered 6-TG release,higher selective therapeutic effect toward cancer cells,and GSH activated T1 weight-magnetic resonance imaging.Based on the above properties,Cu-TG exhibited magnetic resonance imaging (MRI) guiding,efficient and synergistic combination of chemodynamic and chemotherapy with self-reinforcing therapeutic outcomes in vivo.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Haifeng Yuan		1	0	0.0	0.0
2	Yan Zhao		1	0	0.0	0.0
3	Chan Yang		1	0	0.0	0.0
4	Cheng Zhang1		1	0	0.0	0.0
5	Yue Yang		1	0	0.0	0.0
6	Hongmin Meng		1	0	0.0	0.0
7	Shuangyan Huan		1	0	0.0	0.0
8	Guosheng Song		1	0	0.0	0.0
9	Xiaobing Zhang		1	0	0.0	0.0