Long-term survival of occult hepatitis B associated hepatocellular carcinoma following surgery and antiviral therapy

• 作者: Tina Boortalary Ernest Rosato Christopher Roth Xiangdong David Ren Selena Y.Lin Hie-Won Hann
• 来源期刊: 肝癌研究（英文版）
• 年，卷（期）: 2020,（8）
• 所属期刊栏目: Case Report
• 页码范围: 29-35
• 页数: 7页
• 语种: 英文
• DOI: 10.20517/2394-5079.2020.38

摘要

Occult hepatitis B infection (OBI) is characterized by absent hepatitis B surface antigen (HBsAg), low or undetectable serum hepatitis B viral DNA (HBV-DNA), and detectable DNA in the liver. There is debate over whether OBI increases the risk of hepatocellular carcinoma (HCC). We present a patient with negative HBsAg and a large HCC tumor who underwent a large right hepatic lobectomy. Initially, the etiology of HCC was unknown, but through more sensitive molecular testing, it was believed to be due to OBI. In this case report, we discuss the patient's clinical course, the effect of antiviral therapy, mechanism of carcinogenesis in OBI, and the need for more rigorous HBV DNA assay testing for the detection of OBI.