Anti-inflammatory and Scalp Care Efficacy of a Multi-herb Extraction against Malassezia furfur

• 作者: Jun Tian Liu Dong Lu Yina Wang Guoxun
• 来源期刊: 日用化学品科学（英文）
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: Technologies
• 页码范围: 60-66
• 页数: 7页
• 语种: 英文

摘要

Malassezia furfur is a lipophilic and dermatological pathogenic yeast, which normally exists on human skin, and causes tinea versicolor, seborrhoeic dermatitis, and atopic dermatitis, especially on human scalp. The multi-herb extraction VGP which consists of Vitex trifolia fruit, Gentiana scabra, and Polygonum multiflorum root extract was used to study its effect of anti-inflammation, controlling sebum and dandruff on scalp care. Results showed that on the model of NHEK and THP1 cell inflammation induced by Malassezia furfur, VGP can inhibit the expression of interleukin 6 (IL-6), prostaglandin E2 (PGE-2), monocyte chemoattractant protein 1 (MCP-1) and interleukin 1β (IL-1β) in a dose-dependent manner under 0.01％ to 0.125％ concentration. On the inflammatory model of 3D reconstructed skin induced by H2O2, VGP significantly improved the cell viability and skin structure, and reduced the production of interleukin 8 (IL-8), PGE-2, and leukotriene B4 (LTB4). During 4 week's treatment with test shampoo contained 0.5％ VGP thrice a week on 16 subjects met with different symptom, VGP reduced the sebum content and TEWL, improved the redness, itching and dandruff on human scalp skin. Therefore, as a natural active ingredient VGP can play a role in scalp care and skin care by targeting inflammation.