An Antibacterial Wound Dressing Based on GS-SF Composite Scaffold

• 作者: Bin Gao Ping Chen Qifeng Jiang
• 来源期刊: 健康(英文)
• 学科: 医学
• 关键词: Silk Fibroin Gentamicin Sulfate Wound Dressing ANTI-BACTERIAL
• 年，卷（期）: 2020,（8）
• 页码范围: 915-922
• 页数: 8页
• 分类号: R31

摘要

Although the treatment of burn wounds has made great progress, the incidence of wound infection is still the main cause of high mortality. In this study, a silk fibroin (SF) scaffold wound dressing incorporated with Gentamicin Sulfate (GS) was developed for the treatment of burn infected wounds, in which GS was used as anti-bacterial agent. GS was mixed with silk fibroin solution and then processed into GS-SF composite scaffold via electro-spinning. The results showed the scaffold exhibited uniform polyporous morphology with 80% porosity. Induced by methanol, the scaffold presented much improved mechanical properties and stability to protease <em>XIV</em>. More important, the scaffold presented significant growth inhibition on both Gram-positive (<em>Staphylococcus aureus</em>) and Gram-negative (<em>Pseudomonas aeruginosa and Escherichia coli</em>) bacteria.