Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy

• 作者: Xiao-fang Zhong Xun Sun
• 来源期刊: 中国药理学报（英文版）
• 关键词: cancer immunotherapy nanoscale metal-organic frameworks (nMOFs) cancer vaccine in situ vaccination immunomodulators immune response
• 年，卷（期）: 2020,（7）
• 页码范围: 928-935
• 页数: 8页
• 语种: 英文

摘要

Cancer immunotherapy,with an aim to enhance host immune responses,has been recognized as a promising therapeutic treatment for cancer.A diversity of immunomodulatory agents,including tumor-associated antigens,adjuvants,cytokines and immunomodulators,has been explored for their ability to induce a cascading adaptive immune response.Nanoscale metal-organic frameworks (nMOFs),a class of crystalline-shaped nanomaterials formed by the self-assembly of organic ligands and metal nodes,are attractive for cancer immunotherapy because they feature tunable pore size,high surface area and loading capacity,and intrinsic biodegradability.In this review we summarize recent progress in the development of nMOFs for cancer immunotherapy,including cancer vaccine delivery and combination of in situ vaccination with immunomodulators to reverse immune suppression.Current challenges and future perspectives for rational design of nMOF-based cancer immunotherapy are also discussed.