Effect of a Diet Rich in Interesterified, Non-Interesterified and Trans Fats on Biochemical Parameters and Oxidative Status of Balb-c Mice

• 作者: Edson Luiz da Silva Elinete Eliete de Lima Iván Jachmanián Jane Mara Block Josiane Hilbig Luiza S. E. P. W. Castro Nádia S. R. S. Mota Roberta C. da Silva Rodrigo C. Zeferino Rozangela C. Pedrosa Valdelúcia Maria A. de S. Grinevicius
• 来源期刊: 食品与营养科学(英文)
• 学科: 医学
• 关键词: Interesterified Fat Trans Fat Palmitic Acid CHOLESTEROL Oxidative Stress
• 年，卷（期）: 2020,（11）
• 页码范围: 1032-1052
• 页数: 21页
• 分类号: R58

摘要

The aim of this study was</span><span style="font-family:Verdana;"> to investigate the effects of different modified fats on the body weight, biochemical profile, and biomarkers of hepatic oxidative status in Balb-</span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">c</span></i><i><span style="font-family:Verdana;"></i></span></i><i><span style="font-family:""> </span></i><span style="font-family:""><span style="font-family:Verdana;">mice. The animals were divided into four groups and fed for 75 days with a </span><span style="font-family:Verdana;">normolipidic</span><span style="font-family:Verdana;"> (Control Group</span></span><span style="font-family:Verdana;">,</span><span style="font-family:""><span style="font-family:Verdana;"> CG) or </span><span style="font-family:Verdana;">hiperlipidic</span><span style="font-family:Verdana;"> diets (40% kcal) containing a commercial interesterified fat (IFG) rich in palmitic acid (39%);a blend of non-interesterified fat (NIFG), with 2-fold less saturated fatty acids at the </span></span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">sn</span></i><i><span style="font-family:Verdana;"></i></span></i><span style="font-family:""><span style="font-family:Verdana;">-2 position of triacylglycerols;or </span><span style="font-family:Verdana;">a partially</span><span style="font-family:Verdana;"> hydrogenated vegetable oil (</span><span style="font-family:Verdana;">PHFG), source of trans fatty acid (20%) and of linolenic acid (6%). The mice of the IFG and NIFG presented similar results in all evaluated parameters. The serum biochemical profile and hepatic oxidative stress markers in mice of the PHFG were similar to CG, except for total cholesterol (TC) which was significantly higher (p < 0.05) for the mice of th</span><span style="font-family:Verdana;">e PHFG. The mice feed with interesterified fat (IFG) showed serum TC (p < 0.01), non-HDL-C (p < 0.05), glucose (p < 0.05) and hepatic reduced glutathione va