Sleep Disturbance: An Early Sign of Alzheimer's Disease

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2020,（4）
• 页码范围: 449-451
• 页数: 3页
• 语种: 英文

摘要

Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with cognitive impairment in older adults.The accumulation of insoluble forms of amyloid-β (Aβ) in plaques in extracellular spaces and the aggregation of hyperphosphorylated microtubule-associated protein tan in neurofibrillary tangles in neurons are considered to be central pathological features of AD [1,2].Before the cognitive symptoms and pathological signs are present,preclinical synaptic and neuronal injury begins to occur,and this continues for 10-20 years.Currently,one focus of AD research is to discern the preclinical stage of AD,when Aβ deposition has begun to occur but before clear cognitive impairment,as well as to develop therapeutic interventions at this stage to prevent AD progression [3].