The World Health Organization declared that </span><span style="font-family:Verdana;">corona virus</span><span style="font-family:Verdana;"> diseases-19 (COVID-19) is a public health emergency. The COVID-19 pandemic is more likely to cause disaster in developing </span><span style="font-family:Verdana;">area</span><span style="font-family:Verdana;"> including West Africa due to limited medical resources. COVID-19 reportedly causes severer conditions in adults with advanced age and </span><span style="font-family:Verdana;">in</span><span style="font-family:Verdana;"> patients with underlying comorbidities including sickle cell anemia. We recently experienced </span><span style="font-family:Verdana;">two</span><span style="font-family:Verdana;"> pediatric patients with sickle cell disease (SS), who had COVID-19. We here highlight the difficulties of management and the severity of COVID-19 infection in children with homozygous sickle cell SS.