OBJECTIVE: To evaluate the efficacy of scalp-acupuncture on subjects with hemiplegic paralysis of acute ischaemic stroke (AIS).METHODS;One hundred and twenty patients with hemiplegic paralysis of 1 to 7 d post stroke,aged 40 to 75 years,were randomly allocated to receive either standard care (control group) or standard care plus 30 min of scalp-acupuncture applied to the bilateral anterior oblique line of the vertex-temporal (MS6) for 14 d (6 d/week) (trial group).The outcome measures included the National Institutes of Health Stroke scale (NIHSS) for neurological deficits,the Fugl-Meyer assessment (FMA) for limb impairment,and Barthel index (BI) for activities of daily living before and after intervention.The manual muscle test (MMT) was assessed at pre-intervention,at the first post-intervention immediately,and at the 14th day after intervention commencement.Measurements were recorded by a blinded investigator at different time points after initiating the intervention.RESULTS: The trial group had a greater increase in MMT (P < 0.0S),FMA,and BI scores (P< 0.01),and a greater decrease in NIHSS scores (P < 0.01) from pre-intervention to post-intervention,and the control group had a greater increase in MMT scores (P < 0.05),and a greater decrease in NIHSS scores (P < 0.01) from pre-intervention to post-intervention.The improvement in MMT (P < 0.01),FMA,BI (P < 0.05),and NIHSS (P < 0.01) scores in the trial group was superior to that of the control group.Meanwhile,scalp-acupuncture intervention had an immediate effect on myodynamia of patients with hemiplegic paralysis after acute ischaemic stroke in this randomized controlled trial.CONCLUSION: The early scalp-acupuncture intervention after stroke effectively increased myodynamia of the affected limbs,improved neurological deficit degrees,and daily living ability.