Infection within 2 weeks before liver transplantation closely related to prognosis of posttransplant infection: A single-center retrospective observational study in China

• 作者: Hao-Cheng Zhang Jing-Wen Ai Rui-Dong Li Shan-Shan Weng Wen-Hong Zhang Xian Zhou Xin-Chang Chen Xu-Yang Wang Yang Li Yi-Feng Tao Yi-Min Zhu Yi-Qi Yu Yi-Yi Qian Yu-Xian Huang Yue Ying Zheng-Xin Wang
• 来源期刊: 国际肝胆胰疾病杂志(英文版)
• 年，卷（期）: 2020,（4）
• 页码范围: 358-364
• 页数: 7页
• 语种: 英文

摘要

Background: Infections still represent the main factors influencing morbidity and mortality following liver transplantation. This study aimed to evaluate the incidence and risk factors for infection and survival after liver transplantation.Methods: We retrospectively examined medical records in 210 liver recipients who underwent liver trans- plantation between April 2015 and October 2017 in our hospital. Clinical manifestations and results of pathogen detection test were used to define infection. We analyzed the prevalence, risk factors and prog- nosis of patients with infection. Results: The median follow-up was 214 days; the incidence of infection after liver transplantation was 46.7％ ( n = 98) which included pneumonia (43.4％), biliary tract infection (21.9％), peritonitis (21.4％) and bloodstream infection (7.6％). Among the pathogens in pneumonia, the most frequently isolated was Acinetobacter baumanii (23.5％) and Klebsiella pneumoniae (21.2％). Model for end-stage liver disease (MELD) score (OR = 1.083, 95％ CI: 1.045–1.123; P < 0.001), biliary complication (OR = 4.725, 95％ CI: 1.119–19.947; P = 0.035) and duration of drainage tube (OR = 1.040, 95％ CI: 1.007–1.074; P = 0.017) were inde- pendent risk factors for posttransplant infection. All-cause mortality was 11.0％ ( n = 23). The prognostic factors for postoperative infection in liver recipients were prior-transplant infection, especially pneumo- nia within 2 weeks before transplantation. Kaplan-Meier curves of survival showed that recipients within 2 weeks prior infection had a significantly lower cumulative survival rate compared with those without infection (65.2％ vs. 90.0％; hazard ratio: 4.480; P < 0.001). Conclusions: Infection, especially pneumonia within 2 weeks before transplantation, complication with impaired renal function and MELD score after 7 days of transplantation was an independent prognostic factor for postoperative infection in liver transplant recipients.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Yue Ying		1	0	0.0	0.0
2	Rui-Dong Li		1	0	0.0	0.0
3	Jing-Wen Ai		1	0	0.0	0.0
4	Yi-Min Zhu		1	0	0.0	0.0
5	Xian Zhou		1	0	0.0	0.0
6	Yi-Yi Qian		1	0	0.0	0.0
7	Xin-Chang Chen		1	0	0.0	0.0
8	Xu-Yang Wang		1	0	0.0	0.0
9	Hao-Cheng Zhang		1	0	0.0	0.0
10	Yang Li		1	0	0.0	0.0
11	Shan-Shan Weng		1	0	0.0	0.0
12	Yi-Qi Yu		1	0	0.0	0.0
13	Yi-Feng Tao		1	0	0.0	0.0
14	Yu-Xian Huang		1	0	0.0	0.0
15	Zheng-Xin Wang		1	0	0.0	0.0
16	Wen-Hong Zhang		1	0	0.0	0.0