CSF Brain-Reactive Autoantibodies are Elevated in Patients with Viral Encephalitis

• 作者: Gao-Yu Cui Jian-Hong Wang Jie-Xiang Pan Ju Wang Jun Wang Liang Tan Noralyn B.Ma(n)ucat-Tan Shui-Xian Zhang Wei-Wei Li Ye-Ran Wang Yu-Hui Liu Zhong-Yuan Yu Zu-Juan Liu
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2020,（8）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 942-946
• 页数: 5页
• 语种: 英文

摘要

Dear Editor, Brain-reactive autoantibodies are thought to play an important role in mediating disorders of the central nervous system (CNS).These antibodies direct the processes underlying several diseases, such as multiple sclerosis (MS), neuromyelitis optica (NMO), and neuropsychiatric systemic lupus erythematosus [1-3].In infectious diseases of the CNS, the pathogen itself is regarded to play a major role in the pathogenesis [4].In recent years, post-viralautoimmune reactions have been identified to be critical factors that influence the pathogenesis [5, 6].The best understood example is anti-NMDAR (N-methyl-D-aspartate receptor) encephalitis [7], which is commonly caused by viral infections, especially by herpes simplex virus (HSV) infection.