Characterization of metal element distributions in the rat brain following ischemic stroke by synchrotron radiation micro-fluorescence analysis

• 作者: Hui Wang Meng-Qi Zhang Shi-Xin Liu Shu-Peng Shi Xiao-Han Li Zhuo-Hui Chen
• 来源期刊: 核技术（英文版）
• 年，卷（期）: 2020,（10）
• 页码范围: 1-12
• 页数: 12页
• 语种: 英文

摘要

Ischemic stroke is one of the leading causes of death worldwide, and effective treatment strategies in the chronic phase of this disease remain insufficient. Homeostasis of metals in the brain plays an important role in maintaining normal brain function. However, the dynamic spatial distributions of iron, zinc, calcium, potassium, and copper in a rat brain following ischemic stroke and the association between structural distribution and function remain to be elucidated. In this study, we used a synchrotron radiation-based micro-X-ray fluorescence technique to image element mapping changes in special rat brain regions after ischemic stroke, showing the distribu-tion characteristics of iron, zinc, calcium, potassium, and copper. We demonstrated, for the first time, the consistent dynamic spatial distributions of metal elements at a series of time points (3 h, 4.5 h, 6 h, 12 h, 1 d, 3 d, 5 d, 7 d, 10 d, 14 d, 28 d) after brain ischemia, which revealed that the homeostasis of iron, zinc, calcium, potassium, and copper in the brain was disturbed with distinctive change trends, providing clear insights in understanding the underlying pathogenesis of stroke from a novel perspective, thus lay-ing the foundation of further developing new drug targets for stroke treatment.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Shu-Peng Shi	中南大学湘雅医院/中南大学第一临床学院	1	0	0.0	0.0
2	Hui Wang	中南大学湘雅医院/中南大学第一临床学院	1	0	0.0	0.0
3	Zhuo-Hui Chen	中南大学湘雅医院/中南大学第一临床学院	1	0	0.0	0.0
4	Xiao-Han Li	中南大学湘雅医院/中南大学第一临床学院	1	0	0.0	0.0
5	Shi-Xin Liu	中南大学湘雅医院/中南大学第一临床学院	1	0	0.0	0.0
6	Meng-Qi Zhang	中南大学湘雅医院/中南大学第一临床学院	1	0	0.0	0.0