Dysregulated adaptive immune response contributes to severe COVID-19

• 作者: Baosong Xie Bin Zou Bingliang Lin Bo Wei Haibo Zhou Jingjing He Kuai Yu Lai Wei Penghui Zhou Wen Wen Wenxiong Xu Xi Huang Xuefei Liu Yongjian Wu Zhixiang Zuo
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2020,（9）
• 所属期刊栏目: LETTERS TO THE EDITOR
• 页码范围: 814-816
• 页数: 3页
• 语种: 英文

摘要

Dear Editor, The outbreak of the new coronavirus SARS-CoV-2 has resulted in a global pandemic.Due to the lack of a specific drug against this virus, the current clinical management of this disease mainly depends on supportive care to reduce inflammatory responses and to keep the lung functioning.1 Understanding the underlying immunopathology of coronavirus disease 2019 (COVID-19) is therefore of paramount importance for improving the current treatment.In this study, we found a distinct feature of adaptive immunity in severely affected patients, the coincidence of impaired cellular and enhanced humoral immune responses, suggesting that dysregulated adaptive immune responses advanced severe COVID-19.Interestingly, expression of Prothymosin alpha (PTMA), the proprotein of Thymosin alpha-1 (Tα1), was increased in a group of CD8 T memory stem cells accumulated during severe disease.We further showed that Tα1 slightly reduced T cell activation in vitro and promoted proliferation of effector T cells.Moreover, Tcα1 treatment relieved the lymphopenia in COVID-19 patients.Our data suggest that early intervention of adaptive immune response might be critical for the prevention of severe COVID-19.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Kuai Yu		1	0	0.0	0.0
2	Jingjing He		1	0	0.0	0.0
3	Yongjian Wu		1	0	0.0	0.0
4	Baosong Xie		1	0	0.0	0.0
5	Xuefei Liu		1	0	0.0	0.0
6	Bo Wei		1	0	0.0	0.0
7	Haibo Zhou		1	0	0.0	0.0
8	Bingliang Lin		1	0	0.0	0.0
9	Zhixiang Zuo		1	0	0.0	0.0
10	Wen Wen		2	0	0.0	0.0
11	Wenxiong Xu		1	0	0.0	0.0
12	Bin Zou		1	0	0.0	0.0
13	Lai Wei		1	0	0.0	0.0
14	Xi Huang		1	0	0.0	0.0
15	Penghui Zhou		1	0	0.0	0.0