TASK-3: New Target for Pain-Relief

• 作者: Alexey Semyanov Henning Ulrich Peter Illes Wen-Jing Ren Yong Tang
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2020,（8）
• 所属期刊栏目: Research Highlights
• 页码范围: 951-954
• 页数: 4页
• 语种: 英文

摘要

Morphine and other opioids are among the most effective analgesics for treating pain.However, drug dependence and other deleterious side effects of opioids have limited their clinical applicability.Recent studies suggest that the use of opioids for pain control may even exacerbate disease outcomes in some pain-producing conditions, such as acute pancreatitis [1].Thus, there is a clinically unmet demand for the discovery of new therapeutic targets for developing a new generation of analgesics potentially devoid of opioid-like adverse side effects.In most cases, the initial proof-of-concept identification of a protein as a potential druggable target is dependent on the use of genetically modified rodent models, such as gene-knockout mice.