MAGI-2 downregulation: a potential predictor of tumor progression and early recurrence in Han Chinese patients with prostate cancer

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2020,（6）
• 所属期刊栏目: ORIGINAL ARTICLE
• 页码范围: 616-622
• 页数: 7页
• 语种: 英文
• DOI: 10.4103/aja.aja_142_19

摘要

Membrane-associated guanylate kinase (MAGUK) family protein MAGUK invert 2 (MAGI-2) has been demonstrated to be involved in the tumorigenic mechanism of prostate cancer.The objective of this study was to investigate the expression of MAGI-2 at mRNA and protein levels.The prognostic value of MAGI-2 in Han Chinese patients with prostate cancer was also investigated.The expression data of MAGI-2 were assessed through database retrieval,analysis of sequencing data from our group,and tissue immunohistochemistry using digital scoring system (H-score).The clinical,pathological,and follow-up data were collected.The expression of MAGI-2 in prostate tumor tissues and prostate normal tissues was evaluated and compared.MAGI-2 expression was associated with clinical parameters including tumor stage,lymph node status,Gleason score,PSA level,and biochemical recurrence of prostate cancer.The relative expression of MAGI-2 mRNA was lower in the tumor tissue in The Cancer Genome Atlas (TCGA) database and sequencing data (P ＜ 0.001).There was no difference in MAGI-2 protein expression between tumor and normal tissues in tissue microarray (TMA) results.MAGI-2 expression was associated with pathological tumor stage (P =0.02),Gleason score (P =0.05),and preoperation prostate-specific antigen (PSA;P =0.04).A positive correlation was identified between MAGI-2 and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expressions through the analysis of TCGA and TMA data (P ＜ 0.0001).Patients with higher MAGI-2 expression had longer biochemical recurrence-free survival in the univariate analysis (P =0.005),which indicates an optimal prognostic value of MAGI-2 in Han Chinese patients with prostate cancer.In conclusion,MAGI-2 expression gradually decreases with tumor progression,and can be used as a predictor of tumor recurrence in Chinese patients.