A facile and sensitive colorimetric detection for RNase A activity based on target regulated protection effect on plasmonic gold nanoparticles aggregation

• 作者: Qinshu Zhu Renzhong Yu Rui Wang Zhaoyin Wang Zhihui Dai
• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2020,（6）
• 页码范围: 860-864
• 页数: 5页
• 语种: 英文

摘要

In this work,a facile and sensitive colorimetric detection method was firstly reported for RNase A activity detection based on target regulated protection effect of chimeric DNA probe on the salt-induced aggregation of plasmonic gold nanoparticles.Compared with previous works of RNase A activity detection,this colorimetric assay integrated the advantages of sensitive,low cost,facile operation,rapid response and low biological toxicity.