Venous resection at pancreaticoduodenectomy (PD) has estab- lished itself as a viable treatment for borderline resectable can- cer, with equivalent survival to those patients undergoing PD for cancer without venous resection [1] . Thus surgery for these pa- tients is clearly desirable, when possible, compared to palliative care. However, there is concern and debate about the safety of ve- nous resection at PD [2] . There is a need to improve patient path- ways, outcome and experience [3] . To this end, in patients who present with jaundice, it is clear that surgery without preopera- tive biliary drainage (PBD) reduces complications [4] . In 2015, our team introduced a 'fast track' program to routinely perform PD in the presence of jaundice [5] . This change of practice has become routine, with most patients now undergoing surgery without PBD. It is, however, unclear whether portal vein (PV) resection + PD is safe in the setting of jaundice. The aim of this study, therefore, was to compare outcomes and complications between patients with or without jaundice undergoing PD with associated resection of the superior mesenteric vein (SMV) and/or PV.