Nuclear Factor I/A Controls A-fiber Nociceptor Development

• 作者: Guangjuan Yin Lu Qi Mengsheng Qiu Richard M.Gronostajski Xiaohua Wu Yang Liu Yeqi Tao Yongchao Zhang
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2020,（7）
• 页码范围: 685-695
• 页数: 11页
• 语种: 英文

摘要

Noxious mechanical information is transmitted through molecularly distinct nociceptors,with pinprickevoked sharp sensitivity via A-fiber nociceptors marked by developmental expression of the neuropeptide Y receptor 2 (Npy2r) and von Frey filament-evoked punctate pressure information via unmyelinated C fiber nociceptors marked by MrgprD.However,the molecular programs controlling their development are only beginning to be understood.Here we demonstrate that Npy2r-expressing sensory neurons are in fact divided into two groups,based on transient or persistent Npy2r expression.Npy2r-transient neurons are myelinated,likely including A-fiber nociceptors,whereas Npy2r-persistent ones belong to unmyelinated pruriceptors that co-express Nppb.We then showed that the transcription factors NFIA and Runx1 are necessary for the development of Npy2r-transient A-fiber nociceptors and MrgprD+ C-fiber nociceptors,respectively.Behaviorally,mice with conditional knockout of Nfia,but not Runx1 showed a marked attenuation of pinprick-evoked nocifensive responses.Our studies therefore identify a transcription factor controlling the development of myelinated nociceptors.