Tweaking the acid-sensitivity of transiently thermoresponsive polyacrylamides with cyclic acetal repeating units

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2020,（4）
• 页码范围: 504-512
• 页数: 9页
• 语种: 英文

摘要

Merging the characteristics of thermoresponsive and stimuli-degradable polymers yields so-called transiently thermoresponsive polymers,which can find application for the design of injectable gels,nanoparticles,etc.within a biomedical context.Among these polymers,only a limited number is reported which shows selective degradation under mild acidic conditions.However,extension of the library of transiently thermoresponsive polymers is desired to broadening the biomaterials toolbox to suit specific needs.Three monomers were developed by modification of 2-hydroxyethylacrylamide (HEAm) via tetra-hydropyranylation or-furanylation with 3,4-dihydro-2H-pyran (DHP),2,3-dihydrofuran (DHF) or 2,3-dihydro-5-methylfuran (MeDHF).The presence of an acetal or ketal bond provided the monomers a pH-dependent hydrolysis behavior ranging from minutes to days.RAFT polymerisation allowed for the construction of homopolymers with temperature responsive behavior and pH-dependent hydrolysis which was strongly influenced by nature of the monomeric repeating units.