The stability of nanosized catalysts at high temperature is still a challenging topic and is a crucial criterion to evaluate their suitability for industrial use.Currently,the strategy to improve the high-temperature stability ofnano-sized catalysts is to restrict the migration of particles on the surface,which,however,lacks theoretical knowledge and directions.Herein,we reported a new approach that can effectively inhibit the migration and agglomeration of supported nanoparticles by fabrication of a model catalyst Pt/CeO2/NiAl2O4/A12O3@SiO2.This catalyst is highly stable with the microstructure unchanged even after being aged at 1000 ℃.Density functional theory calculations indicate that two types of confinement effects exist in the catalyst and their mechanisms were well explained from the viewpoint of "energy traps" which can also be applied to other supported catalysts.