Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

• 作者: Chan Yang Shu-wen Liu Wei Xu Xin-feng Xu Yuan Huang
• 来源期刊: 中国药理学报（英文版）
• 年，卷（期）: 2020,（9）
• 所属期刊栏目: Review Article
• 页码范围: 1141-1149
• 页数: 9页
• 语种: 英文

摘要

Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world.It is caused by a novel coronavirus,severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).The spike (S) protein of SARS-CoV-2,which plays a key role in the receptor recognition and cell membrane fusion process,is composed of two subunits,S1 and S2.The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2,while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain.In this review,we highlight recent research advance in the structure,function and development of antivirus drugs targeting the S protein.