Polycyclic naphthalenediimide-based nanoparticles for NIR-Ⅱ fluorescence imaging guided phototherapy

• 作者: Chen Liang Chuanchao Tang Chuanhui Song Jianchuan Ran Wei Han Xiaochen Dong Yu Cai Zheng Wei
• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2020,（7）
• 页码范围: 946-956
• 页数: 11页
• 语种: 英文

摘要

Optical imaging and phototherapy in the second near-infrared window (NIR-Ⅱ,900-1700 nm) can reduce tissue auto-fluorescence and photon scattering,which facilitates higher spatial resolution and deeper tissue penetration depth for solid tumor theranostics.Herein,a polycyclic naphthalenediimide (NDI) based chromophore 13-amino-4,5-dibromo-2,7-di(dodecan-6-yl)-1H-isoquinolino[4,5,6-fgh]naphtho[1,8-bc][1,9]phenanthroline-1,3,6,8(2H,7H,9H)-tetraone (NDI-NA) was designed and synthesized.With large polycyclic g-systems,NDI-NA molecule possesses broad near-infrared (NIR) absorption (maximum at 777 nm) and emission (maximum at 921 nm).By nanoprecipitation,NDI-NA nanoparticles (NPs) were formed in aqueous solution with J-aggregative state,which showed huge red-shift in both absorption spectrum (maximum at 904 nm) and emission spectrum (maximum at 1,020 nm),endowing NDI-NA NPs efficient NIR-Ⅱ fluorescence imaging capability.Besides,the NPs present effective tumor-targeting capability in vivo based on the enhanced permeation and retention (EPR) effect.More im portantly,NDI-NA NPs simultaneously have high photothermal conversion efficiency (30.8％) and efficient reactive oxygen species generation ability,making them remarkably phototoxic to cancer cells.The polycyclic chromophore based multifunctional NDI-NA NPs as NIR-Ⅱ phototheranostic agents possess bright future for clinical NIR-Ⅱ imaging-guided cancer phototherapy.