Adaptive convergence at the genomic level-prevalent, uncommon or very rare?

• 作者: Shaohua Xu Suhua Shi Ziwen He
• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2020,（6）
• 页码范围: 947-951
• 页数: 5页
• 语种: 英文
• DOI: 10.1093/nsr/nwaa076

摘要

Convergent evolution is one of the central topics in evolutionary genetics [1].While there has been ample evidence of phenotypic convergence,the issue is whether each and any of the phenotypic convergences have an underlying cause in genic convergence [2,3].Fortunately,the torrent of genomic data has made it possible to address the issue [4-8].Convergence can happen at multiple levels of the genetic architecture.For example,many studies have reached the conclusion of genic convergence when the same gene has experienced many more amino acid (AA) changes than expected [3,9-11].Another prominent example is the TCGA (The Cancer Genome Atlas) data on the evolution of tumors,whereby convergence is defined as the sharing of mutations in the same genes,rather than the same change at the same site [12,13].Many others have further relaxed the stringency in defining convergent evolution.For example,convergence could also mean copy number or evolutionary rate changes in the same genes [14,15].