Genotoxicity Clues to Predict Intervertebral Disc Degeneration: A Systematic Review

• 作者: Asdrubal Falavigna Bruno Saciloto Charles André Carazzo Manuela Peletti Figueiró Natalia Fontana Nicoletti
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: DNA Damage GENOTOXICITY BIOMARKER Intervertebral Disc Degeneration
• 年，卷（期）: 2020,（12）
• 页码范围: 68-77
• 页数: 10页
• 分类号: R59

摘要

<strong>Objective:</strong> To characterize the association between DNA damage and Intervertebral disc degeneration (IDD). <strong>Summary of</strong> <strong>Background Data:</strong> IDD is the main disorder causing low back pain and is the most promising target for intervention. Many factors can contribute to the etiology, such as genetics, environment and lifestyle, but it is not yet fully understood. DNA damage can influence this process and needs to be studied, as well as the agents that can determine these damages. <strong>Methods:</strong> A systematic literature search of PubMed, Web of Science and Scopus was performed to identify studies related to DNA damage to the intervertebral disc. <strong>Results:</strong> After screening 61 records, 7 articles were included according to the selection criteria. All studies showed some relation between DNA damage and IDD. However, DNA damage was always considered a secondary issue to be investigated. <strong>Conclusions:</strong> Many factors can influence DNA damage induced by different genotoxic agents on the degenerative cascade of IVD. However, the correlation between IDD severity and DNA damage, as well as the factual role of DNA damage in disc degeneration could not be defined.