Construction of MoS2 field effect transistor sensor array for the detection of bladder cancer biomarkers

• 作者: Bo Zeng Huageng Liang Quan Yuan Yanbing Yang Yingxue Li Yujie Yang
• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2020,（7）
• 页码范围: 997-1003
• 页数: 7页
• 语种: 英文

摘要

Bladder cancer is one of the commonest malignant tumors of urinary system with high recurrence.However,currently developed bladder cancer urine diagnosis methods are hindered by the low detection sensitivity and accuracy.Herein,a molybdenum disulfide (MoS2) nanosheets-based field effect transistor (FET) sensor array was constructed for simultaneous detection of multiple bladder cancer biomarkers in human urine.With the excellent electronic property of MoS2 and the high specific identification capability of recognition molecules,the proposed biosensor array could simultaneously detect nuclear matrix protein 22 (NMP22) and cytokeratin 8 (CK8) with a wide linear range of 10-6-10-1 pg mL 1 and an ultra-low detection limit of 0.027 and 0.019 aM,respectively.Furthermore,this highly sensitive and specific MoS2 FET sensor array could be used to identify bladder cancer biomarkers from human urine samples.This designed high-performance biosensor array shows great potential in the future diagnosis of bladder cancer.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Yujie Yang		1	0	0.0	0.0
2	Bo Zeng		1	0	0.0	0.0
3	Yingxue Li		1	0	0.0	0.0
4	Huageng Liang		1	0	0.0	0.0
5	Yanbing Yang		1	0	0.0	0.0
6	Quan Yuan		1	0	0.0	0.0