Arenesulfonyl Fluoride Synthesis via Copper-free Sandmeyer-type Fluorosulfonylation of Arenediazonium Salts

• 作者: Changge Zheng Chao Liu Qing-Yun Chen Qiongzhen Lin Xiao-Jun Hu Yong Guo Zhanhu Ma
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2020,（10）
• 所属期刊栏目: Concise Reports
• 页码范围: 1107-1110
• 页数: 4页
• 语种: 英文
• DOI: 10.1002/cjoc.202000175

摘要

The limited availability of highly valuable arenesulfonyl fluorides seriously hinders their further application in many research fields including medicinal chemistry and chemical biological,organic synthesis,polymer preparation,etc.We report herein a mild and efficient copper-free Sandmeyer-type fluorosulfonylation reaction of various arenediazonium salts to prepare valuable arenesulfonyl fluorides using K2S2O5 as both a reductant and a practical sulfonyl source in combination with N-fluorobenzenesulfonimide as an effective fluorine source.This methodology provides an attractive route to diverse important arenesulfonyl fluorides given the overall practicality and scope.