Ferrimagnetic mPEG-b-PHEP copolymer micelles loaded with iron oxide nanocubes and emodin for enhanced magnetic hyperthermia-chemotherapy

• 来源期刊: 国家科学评论（英文版）
• 关键词: magnetic hyperthermia therapy sensitive thermal response chemotherapy magnetic targeting theranostics
• 年，卷（期）: 2020,（4）
• 页码范围: 723-736
• 页数: 14页
• 语种: 英文
• DOI: 10.1093/nsr/nwz201

摘要

As a non-invasive therapeutic method without penetration-depth limitation,magnetic hyperthermia therapy (MHT) under alternating magnetic fidd (AMF) is a clinically promising thermal therapy.However,the poor heating conversion efficiency and lack of stimulus-response obstruct the clinical application ofmagnetofluid-mediated MHT.Here,we develop a ferrimagnetic polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane) (mPEG-b-PHEP) copolymer micelle loaded with hydrophobic iron oxide nanocubes and emodin (denoted as EMM).Besides an enhanced magnetic resonance (MR) contrast ability (r2 =271 mM-1 s-1) due to the high magnetization,the specific absorption rate (2518 W/g at 35 kA/m) and intrinsic loss power (6.5 nHm2/kg) of EMM are dozens of times higher than the clinically available iron oxide nanoagents (Feridex and Resovist),indicating the high heating conversion efficiency.Furthermore,this composite micelle with a flowable core exhibits a rapid response to magnetic hyperthermia,leading to an AMF-activated supersensitive drug release.With the high magnetic response,thermal sensitivity and magnetic targeting,this supersensitive ferrimagnetic nanocomposite realizes an above 70％ tumor cell killing effect at an extremely low dosage (10μg Fe/mL,),and the tumors on mice are completely eliminated after the combined MHT-chemotherapy.