New Insights into the Dysfunctions of Pericytes and Neurovascular Units in Neurodegenerative Diseases

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Research Highlights
• 页码范围: 1570-1572
• 页数: 3页
• 语种: 英文

摘要

The neurovascular unit(NVU)is an essential anatomical and physiological entity for the maintenance of brain homeostasis and function;it is composed of endothelial cells,pericytes,astrocytes,neurons,vascular smooth muscle cells,microglia,and oligodendroglia[1].The NVU regulates important brain vessel properties such as the integrity of the blood-brain barrier(BBB)and cerebral blood flow(CBF).Considerable efforts have been made to investigate the cerebral microcirculatory dysfunction in ageing and Alzheimer's disease(AD)[2].