Synthesis, Crystal Structure and Biological Activities of Phenyl(6-phenyl-3-p-tolyl-6,7-dihydro-5H-[1,2,4]triazolo-[3,4-b] [1,3,4]thiadiazin-7-yl)methanone

• 作者: DING Qi-Chun HUANG Jian-Jun LI Qiu-Ling YIN Hui-Yong ZHANG Li-Xue ZOU Yi-Hui
• 来源期刊: 结构化学
• 年，卷（期）: 2020,（8）
• 页码范围: 1531-1538
• 页数: 8页
• 语种: 英文
• DOI: 10.14102/j.cnki.0254-5861.2011-2671

摘要

The title compound phenyl(6-phenyl-3-p-tolyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl)methanone (PTM),designed using 4-amino-3-p-tolyl-1H-1,2,4-triazole-5(4H)-thione as the starting material,was successfully synthesized via a two-step synthesis route and fmally characterized by NMR,FT-IR,single-crystal X-ray diffraction and mass spectrometry techniques.The crystal structure of trans-PTM was obtained from X-ray diffraction: C24H20N4OS,Mr =412.52,monoclinic system,space group P21/c,a =16.650(3),b =13.876(3),c =8.812(2) (A),β =100.340(3)°,V=2002.8(7) (A)3,F(000) =865,Z =4,Dc =1.3680 g/cm3,λ =0.71073 (A),μ =0.186 mm-1 and the final R =0.0786 for 3514 unique reflections with 2044 observed ones (Ⅰ ＞ 2σ(Ⅰ)).The biological activities of antimicrobial and regulation of plant growth of PTM were investigated.The results indicated that PTM showed weak antimicrobial activity on Bacillus pumilus,while promoted the growth of radish and inhibited that of wheat in a dose-dependent manner.Therefore,PTM may be developed as a potential drug to promote the growth of dicotyledonous plants or as an herbicide to inhibit that of monocotyledonous plants in the future.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	DING Qi-Chun		1	0	0.0	0.0
2	ZOU Yi-Hui		1	0	0.0	0.0
3	LI Qiu-Ling		1	0	0.0	0.0
4	HUANG Jian-Jun		1	0	0.0	0.0
5	ZHANG Li-Xue		1	0	0.0	0.0
6	YIN Hui-Yong		1	0	0.0	0.0