Manipulating the superconducting states of high transition temperature (high-To) cuprate superconductors in an efficient and reliable way is of great importance for their applications in next-generation electronics.Here,employing ionic liquid gating,a selective control of volatile and non-volatile superconductivity is achieved in pristine insulating Pr2CuO4±δ (PCO) films,based on two distinct mechanisms.Firstly,with positive electric fields,the film can be reversibly switched between superconducting and non-superconducting states,attributed to the carrier doping effect.Secondly,the film becomes more resistive by applying negative bias voltage up to-4 V,but strikingly,a non-volatile superconductivity is achieved once the gate voltage is removed.Such phenomenon represents a distinctive route of manipulating superconductivity in PCO,resulting from the doping healing of oxygen vacancies in copper-oxygen planes as unravelled by high-resolution scanning transmission electron microscope and in situ X-ray diffraction experiments.The effective manipulation of volatile/non-volatile superconductivity in the same parent cuprate brings more functionalities to superconducting electronics,as well as supplies flexible samples for investigating the nature of quantum phase transitions in high-Tc superconductors.