Highly Regio-,Diastereo-,and Enantioselective Assembly of Azepino[2,3-b]indoles via Palladium-Catalyzed[4 + 3]Cycloaddition

• 作者: Wu-Lin Yang Zesheng Huang Yang-Zi Liu Xingxin Yu Wei-Ping Deng
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Concise Reports
• 页码范围: 1571-1574
• 页数: 4页
• 语种: 英文
• DOI: 10.1002/cjoc.202000264

摘要

A palladium-catalyzed asymmetric[4 + 3]cycloaddition of trimethylenemethanes and indoline-derived aza-dienes has been developed.The potential[3 + 2]side pathway was completely suppressed in the process.This protocol provides an efficient access to azepino(2,3-b]indoles bearing two vicinal stereocenters in generally excellent diastereo-and enantioselectivities(up to ＞20:1 dr,99％ ee).