Activatable nanoscale metal-organic framework for ratiometric photoacoustic imaging of hydrogen sulfide and orthotopic colorectal cancer in vivo

• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2020,（9）
• 所属期刊栏目: ARTICLES
• 页码范围: 1315-1322
• 页数: 8页
• 语种: 英文

摘要

Nanoscale metal-organic frameworks (nano MOFs) have emerged as a promising biomedical nanoplatform because of their unique properties.However,the exploration ofnano MOFs in photoacoustic (PA) imaging is still limited.Here,a novel hydrogen sulfide (H2S)-activated nano copper-based MOF (Cu-MOF) was developed as a near-infrared (NIR) ratiometric PA probe for in vivo monitoring of endogenous H2S level and orthotopic colorectal cancer imaging via in situ reaction of nano Cu-MOFs with endogenous H2S that is closely associated with tumor growth and proliferation in colon cancer.The synthesized nano Cu-MOFs displayed excellent PA responsiveness towards tumor H2S level with high selectivity and rapid kinetics.The result suggests the developed probe may provide a unique opportunity to investigate the malignant behaviors of H2S-associated events in vivo.