Anterior segment parameters associated with extramuscular manifestations in polymyositis and dermatomyositis

• 作者: Adam Kemeny-Beke Gabor Nemeth Judit Zsuga Katalin Danko Katalin Szabo Levente Bodoki Peter Szodoray Rudolf Gesztelyi Ziad Hassan Zoltan Griger Zsuzsa Aszalos
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: dry eye extramuscular manifestations DERMATOMYOSITIS POLYMYOSITIS Scheimpflug imaging
• 年，卷（期）: 2020,（9）
• 页码范围: 1443-1450
• 页数: 8页
• 分类号: R777.34

摘要

AIM:To evaluate detailed anterior segment parameters of patients with idiopathic inflammatory myopathies(IIM),including polymyositis(PM),and dermatomyositis(DM),and to clarify the associations between these data and clinical variables of IIM.METHODS:Totally 57 PM,41 DM patients and 62 controls were enrolled in this cross-sectional,observational,case-control study.All study participants underwent Pentacam evaluation.Laboratory investigations consisted of different antibody assays,while extramuscular clinical assessments included Raynaud’s phenomenon,dysphagia,interstitial lung disease,arthritis/arthralgia,and weight loss.Objective signs and subjective symptoms of dry eye disease(DED)were also evaluated.RESULTS:All pachymetric parameters[center,apex,thinnest and maximal keratometry(Kmax)]and corneal volume(CV)of both sides of PM patients proved to be significantly lower.Some pachymetric data were also noticed as significantly decreased compared to those of controls.Several significant differences were traced between anterior segment values and extramuscular manifestations of myositis,largely in case of arthritis/arthralgia and weight loss,whereas associations between anterior segment parameters and antibodies were weak.Objective clinical tests of DED were also significantly decreased in IIM patients.CONCLUSION:The results suggest that all IIM patients have thinner corneas compared with those of controls,and decreased corneal parameters are significantly associated with the occurrence of some extramuscular manifestations.In addition,IIM patients tend to develop objective signs of DED.