Heightened protein-translation activities in mammalian cells and the disease/treatment implications

• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: PERSPECTIVES
• 页码范围: 1851-1855
• 页数: 5页
• 语种: 英文
• DOI: 10.1093/nsr/nwaa066

摘要

After cells divide,the new cells have to synthesize all the necessary cellular com-ponents in time for the next division.There is a lower bound of time required for cells to double their contents.For mammalian cells,this lower bound may be around 20 hours,as artificial selection for faster-dividing cells has not pushed cell lines to go below this 'barrier'in dou-bling time.The occasional exceptions are those that appear to 'prove the rule'.For example,yeast cells can divide once ev-ery 1.5 hours[1,2],and the fastest rate of cell divisions in metazoans maybe that of the embryonic cells of Drosophila,at 5 minutes per cycle[3].Thus,at least for eukaryotic cells,the rate-limiting step is not the replication of DNA.