Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy

• 作者: Chen Yang Jing Lin Junle Qu Nicholas Thomas Blum Peng Huang
• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2020,（17）
• 页码范围: 1489-1504
• 页数: 16页
• 语种: 英文

摘要

Immunotherapy has attracted tremendous attention due to the remarkable clinical successes for treating a broad spectrum of tumors.One challenge for cancer immunotherapy is the inability to control localization and sustain concentrations of therapeutics at tumor sites.Local drug delivery systems (LDDSs) like the biomaterial scaffold-based drug delivery systems have emerged as a promising approach for delivering immunotherapeutic agents facilely and intensively in situ with reduced systemic toxicity.In this review,recent advances in biomaterial scaffold-based LDDSs for the administration of immunotherapeutic agents including vaccines,immunomodulators,and immune cells are summarized,Moreover,codelivery systems are also evaluated for local immunotherapy-involving combination anti-tumor therapy,including chemotherapy-immunotherapy,photothermal-immunotherapy,and other combination therapies.Finally,the current challenges and future perspectives on the development of next-generation LDDSs for cancer immunotherapy are discussed.