Role of18F-FDG SPECT / CT imaging in the diagnosis and initial staging of lymphoma

• 作者: Jia-Ling Zhong Li-Qing Fu Liang-Qian Tong Sheng-Nan Jiang Yan-Fang Sui Yan-Hai Yin
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2020,（17）
• 页码范围: 52-56
• 页数: 5页
• 语种: 英文

摘要

Objective:To investigate the role of18F-FDG SPECT/PET in the diagnosis and initial staging of lymphoma.Methods:A retrospective analysis was carried out on 48 patients in Haikou Hospital from January 2015 to June 2018, who were eventually pathologically diagnosed with lymphoma and had undergone18F-FDG SPECT/PET before definite diagnosis. (1) Patients were divided into Hodgkin's lymphoma group, diffuse large B cell lymphoma group and other non-Hodgkin's lymphoma group according to Pathological classification; and were divided into nodal lymphoma group and extranodal lymphoma group according to the presence of invasion to the tissues beyond lymph node; and were divided into stage I+Ⅱ group and stage Ⅲ+IV group according to clinical Ann Arbor staging. The diagnostic consistencies of18F-FDG SPECT/PET and conventional imaging (CI) in each group were calculated, the T/N ratios of the lymphoma lesion were analyzed as well. (2) Clinical Ann Arbor staging, SPECT/PET staging and CI staging were performed in 48 patients, respectively. Then the efficacy of SPECT/PET staging and CI staging was compared, and the consistency of SPECT/PET staging and clinical Ann Arbor staging was compared as well.Results:(1) In this study, the diagnostic consistent rates of18F-FDG SPECT/PET and CI were 45.8％ (22/48) and 16.6％ (8/48), respectively (χ2=9.503,P=0.002<0.01). (2) The diagnostic consistent rate of18F-FDG SPECT/PET in diffuse large B cell lymphoma group and other non-Hodgkin's lymphoma group was higher than that of CI (P < 0.05). There was no statistical significance between the diagnostic consistent rates of18F-FDG SPECT/PET in the Hodgkin's lymphoma group, diffuse large B cell lymphoma group and other non-Hodgkin's lymphoma group (χ2=1.067, P=0.448>0.05). (3) The diagnostic consistent rates of18F-FDG SPECT/PET in nodal group and extranodal group were 100.0％ (19/19) and 21.1％ (4/19) (χ2=24.783,P=0.000<0.01) , respectively. (4) The diagnostic consistent rates of18F-FDG SPECT/PET and CI were 25％ (2/8) and 0 (0/8) in lymphoma with early stage(stage I+Ⅱ group) (χ2=2.268,P=0.131>0.05), and 50％ (20/40) and 20％ (8/40) in lymphoma with late stage (stage Ⅲ+IV group) (χ2=7.912,P=0.002<0.01), respectively. (5) There was no statistical significance in T/N ratios of lymphoma lesions between different pathological groups, between nodal group and extranodal group, or between the stage I+Ⅱ group and the stage Ⅲ+IV group (P > 0.05). (6) The total consistent rates of18F-FDG SPECT/PET and CI for initial lymphoma staging were 79.2％ (38/45) and 64.4％ (31/48) (χ2=18.774,P=0.000<0.01). SPECT/PET staging was well consistent with clinical Ann Arbor staging in initial lymphoma staging (Kappa=0.696, P=0.000<0.01).Conclusion:The research has showed that the consistent rates of18F-FDG SPECT/PET in the diagnosis and initial staging of lymphoma are relatively high, and18F-FDG SPECT/PET plays an important role in the diagnosis and initial staging of lymphoma.