Berberine(BBR) is an isoquinoline alkaloid that can be extracted from the traditional Chinese medicine Huang Lian. It has anti-inflammatory, anti-cancer, protection of nerves, hypoglycemic, blood lipid, anti-oxidation, antibacterial and other effects. It can be used clinically to treat chronic colitis, bacterial vaginitis, rheumatoid arthritis, breast cancer, liver cancer, Alzheimer's disease, diabetes, obesity and other common diseases. This paper reviews the pharmacological effects of berberine and the research progress of effective drug carriers in order to provide new ideas for the clinical application of berberine.