Over the latest years, both randomized controlled trials (RCTs) and observational studies have provided solid basisfor percutaneous coronary intervention as a treatment option for unprotected left main (LM) bifurcation coronary artery disease.A recent meta-analysis comparing the long-term outcome between LM bifurcation disease one-stent technique versus twostent technique, the study has demonstrated that one-stent strategy resulted associated with both major adverse cardiac events and target lesion revascularizations (TLRs) lower rates but resulted equivalent to two-stent strategy in terms of cardiovascular mortality, target lesion failure and stent thrombosis (ST) even at one-year and three-year follow-up.[1] However, previous analyses have mainly focused on the type of double stent strategy adopted, as well as bifurcation geometrical properties (i.e., bifurcation angle, side branch length, and etc) or different biodegradable polymer.On the contrary, the impact of stents strut thickness has been generally neglected in current literature.